Biases can blind you to facts

 We all have biases, some of which we are not even aware. If you are a creationist, you are biased against all the science that threatens creationism, but not that which benefits you, because you use and trust those. If you’re with the Pope’s acceptance of evolution “by God,” you will gravitate toward the confirmation bias that manipulates science to fit the Book of Genesis.

If you are biased in favour of big industry, you may criticize science only pertaining to global—warming data, but not the science of fossil fuel as energy.

If you love gun ownership, you will embrace the science of ballistics and explosives and only disagree with the science of death by gunfire statistics, and seek confirmation bias toward a political party that supports your wishes while not being acutely aware of the party’s motives; for example, getting funding from the NRA. You may also support this party regardless of its behavior in other ways, depending on how strong your desire to own guns is.

Please notice: No matter what the bias is if it isn’t founded on evidence, it propagates by attacking science. This is the common denominator of wrong biases. That is because the pillar of logic and the center of truth is science, which must be defeated by all who misrepresent truth.

If you believe that COVID is not a threat, you will discredit all the science that proves it is a threat, and believe only the science that supports your worldview. If you include, create, or believe lies, or twist science, to confirm your bias, you become part of the problem that’s gripping the world. Flat earth believers who are wise enough to use science are very bold liars indeed because they know exactly how they are misrepresenting the scientific disclosure they are using, forcing it to support their flat earth bias. 

Cataract surgery a thing of the past?

I had cataract surgery about five years ago, and it was a success. After my surgery, I no longer had to wear glasses. Many of my friends are going to be needing this surgery over the next few years, so the following could be great news for them.

Cataract surgery could soon be a thing of the past. At least that’s what two studies, one published in Nature and the other in Science, suggest.

Cataracts are cloudy regions that develop in the lens of the eye. They take years to form, but can be dissolved in a matter of weeks with a substance called lanosterol, a precursor to cholesterol and several related sterols.

The Nature paper showed that an injection followed by eye drops containing lanosterol reversed clouding in the lenses of dogs after treating them for just six weeks. Veterinarians may soon be able to substitute eye drops for the scalpel to treat their canine patients, which is just as well as cataracts are common in some pedigree dogs including, ironically, guide dogs for the blind.

The Science paper reports the discovery of a class of small molecules also derived from cholesterol. These sterols were shown to reverse lens clouding in mice and, remarkably, the effects were seen in just two weeks.

Surgeon shortage

Cataracts and the clouding that happens as a result of protein aggregation was considered a point of no return. Until these two new studies came along, no one even thought that restoring the transparency of the lens was an alternative. These papers change that perspective and open a completely new therapeutic strategy to treat cataracts in the future.

Cataracts occur as a result of protein clumping together on the eye’s lens, preventing light from reaching the retina. Once the cataract is formed, there is one option: surgery. Cataract surgery involves removing the natural lens through tiny incisions and replacing it with a plastic “intraocular” lens.

Cataract surgery is one of the most commonly performed procedures and it has a high success rate. The problem is that there simply aren’t enough ophthalmic surgeons to perform all of the procedures that are needed.

In 2010, there were 95m people requiring cataract surgery, worldwide, and of these people 20m were blind as a result. With people living longer, the problem is only going to get worse.

If you live long enough, you will develop cataracts. So something that radically shifts not only our understanding of cataracts but also its treatment is badly needed. And the two recent studies may be just that something. They herald the most remarkable discovery to emerge in the field of cataract therapies since Harold Ridley developed the intraocular lens in the mid-20th century.

It’s not just cataracts

The Science paper shows that selected sterols could help in the treatment of a host of other human diseases such as cardiomyopathy and neurodegenerative diseases where similar proteins are involved. As more details on the mechanism of action become known, it is possible that such sterol-based drugs could have applications for the treatment of Parkinson’s disease, Alzheimer’s disease and other types of dementia.

Another possible application for sterol-based treatments is presbyopia (long-sightedness). This is the other universally experienced ageing effect on the eye lens. When we reach middle age, our arms need to grow a couple inches every year so we can continue to type and read the computer screen. It is believed that presbyopia is the first stage in age-related cataracts. By mid-life, the lens proteins have accumulated significant damage, enough to change their properties and start the process of forming “aggregates” that eventually become a cataract. So the research described in the two papers really does offer something momentous: the preservation of our sight as we age.

Source: The Conversation